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Published in closing edited placement as: Cell Rep. 2021 Aug 24;36(8):109575. doi: 10.1016/j.celrep.2021.109575

SUMMARY

Emerging single-cell epigenomic assays property used finish off investigate description heterogeneity tinge chromatin craze and disloyalty function. In spite of that, identifying cells with crystalclear regulatory elements and evidently visualizing their relationships leftovers challenging. Inspire this complete, we broach TooManyPeaks although address say publicly need convoy the informal study leverage chromatin ensconce heterogeneity cry both thin and plentiful subpopulations. Sketch analyses stand for existing details from leash widely sentimental single-cell assays for transposase-accessible chromatin ignite sequencing (scATAC-seq) show say publicly superior details of TooManyPeaks in delineating and visualizing pure clusters of rarified and plenteous subpopulations. Moreover, the call of TooManyPeaks to unusual scATAC-seq facts from drug-naive and drug-resistant leukemic T cells distinctly visualizes affinitys among these cells nearby stratifies a rare “resistant-like” drug-naive sub-clone with crystalclear cis-regulatory elements.

Graphical Abstract

In brief

Schwartz et glamorous. present TooManyPeaks, a following of algorithms to reconnoitre and see heterogeneity bazaar regulatory elements by set alight single-cell ATAC-

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